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Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.
Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ*, Kranzusch PJ*.
Nature. 2019; 567(7747), 194199. (Link)

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.
Eaglesham JB, Pan Y, Kupper TS, Kranzusch PJ.
Nature. 2019; 566(7743), 259263. (Link)

Structure of the human cGASDNA complex reveals enhanced control of immune surveillance.
Zhou W*, Whiteley AT*, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ.
Cell. 2018; 174(2), 300311. (Link)

Contact

Philip J. Kranzusch, Ph.D.
Assistant Professor of Microbiology
Harvard Medical School
Dana-Farber Cancer Institute
philip_kranzusch [at] dfci.harvard.edu

? 2019, Kranzusch Lab

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